Glycosyl compounds
Medchemexpress LLC Klotho beta Human 10ug | 10ug
Klotho beta protein plays a critical role in the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1) a key enzyme controlling bile acid synthesis Although its glycosidase activity may be inactive Klotho beta enhances the binding ability of FGFR1 and FGFR4 to FGF21 promoting their interaction Klotho beta Protein Human (HEK293 His) is the recombinant human-derived Klotho beta protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC beta-Mangostin | 20931-37-7 | 424.49 | 1 ML
beta-Mangostin (β-Mangostin) is a xanthone compound found in *Cratoxylum arborescens*. It exhibits antibacterial and antimalarial activities, including antimycobacterial activity against *Mycobacterium tuberculosis* and *in vitro* antimalarial activity against *Plasmodium falciparum*. It also shows potent anticancer activity against various cancers, such as hepatocellular carcinoma and leukaemic.
- Xanthone compound
- Antibacterial activity
- Antimalarial activity
- Potent anticancer activity
Medchemexpress LLC Pulsatilla saponin D | 68027-15-6 | 913.10 | 1 ML
Pulsatilla saponin D (SB365), also known as Hederacolchiside A, is a natural product isolated from the root of Pulsatilla chinensis. It is an anti-tumor agent.
- Shows apoptotic effect.
- Strongly inhibits c-Met expression in gastric cancer cells.
- Suppresses the growth and proliferation of 5 human pancreatic cancer cell lines.
- Exhibits anti-angiogenic activity.
- Shows anti-tumor activity in NSCLC cancer cells.
- Demonstrates anti-tumor activity in a Lewis lung carcinoma model.
Medchemexpress LLC IL-1 beta Human C- 10ug | 10ug
IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses It induces inflammatory events including prostaglandin synthesis neutrophil activation and cytokine production IL-1 beta Protein Human (C-His) is the recombinant human-derived IL-1 beta protein expressed by E coli with C-6 His labeled tag
Medchemexpress LLC D-Allose | 2595-97-3 | 99.9% | 1 ML
D-Allose exhibits antitumor activity against various cancer cells. It scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. This compound also shows anti-inflammatory and neuroprotective effects by inhibiting the TLR4/PI3K/AKT signaling pathway. Additionally, D-Allose demonstrates antihypertensive, cryoprotective, and anti-osteoporotic activities.
- Antitumor activity against various cancer cells.
- Scavenges reactive oxygen species (ROS) and reduces oxidative stress damage.
- Anti-inflammatory and neuroprotective effects.
- Antihypertensive, cryoprotective, and anti-osteoporotic activities.
- Inhibits OVCAR-3 cancer cell proliferation and induces apoptosis.
- Upregulates cell cycle inhibitors p21 and p27, arresting cell cycle at G2/M phase.
Medchemexpress LLC Methyl β-D-Galactopyranoside | 1824-94-8 | 99.9% | 1 G
Methyl β-D-Galactopyranoside is an endogenous metabolite appearing as a white to off-white solid. It is intended for research use only.
- Endogenous metabolite
- For research use only
- White to off-white solid appearance
Medchemexpress LLC Sapintoxin D | 80998-07-8 | 99.9% | 1 MG
Sapintoxin D is a fluorescent phorbol ester used for studying the activation of protein kinase C (PKC). It acts as a calcium-dependent PKC activator and exhibits antiviral activity against HIV2 ROD, HIV1 3B in MT4 cells, and chikungunya virus in Vero cells. Its molecular weight is 539.62, and its formula is C30H37NO8. It appears as a white to off-white solid and is derived from Plants Euphorbiaceae Shirakiopsis indica (Willd.) Esser. It is intended for research use only.
- Fluorescent phorbol ester
- Utilized for studying the activation of protein kinase C (PKC)
- Calcium-dependent PKC activator
- Demonstrated antiviral activity against HIV2 ROD and HIV1 3B in MT4 cells
- Demonstrated antiviral activity against chikungunya virus in Vero cells
- White to off-white solid appearance
- Derived from Plants Euphorbiaceae Shirakiopsis indica
- For research use only
Apexbio Technology LLC ISRIB (trans-isomer) 1597403-47-8 25mg
ISRIB (trans-isomer) (CAS 1597403-47-8) is a small molecule inhibitor of the integrated stress response (ISR) ISR activation involves the phosphorylation of eukaryotic initiation factor 2 (eIF2 ) by stress-sensitive kinases leading to reduced global protein synthesis and enhanced translation of select mRNAs ISRIB counteracts ISR signaling by reversing the translational suppression induced by phosphorylated eIF2 inhibiting production of ATF4 protein decreasing stress granule assembly and promoting polyribosome formation during endoplasmic reticulum (ER) stress ISRIB stabilizes and activates eIF2B by facilitating its dimerization Rodent studies demonstrate ISRIB s capacity to enhance hippocampal-dependent spatial and fear-related learning and memory highlighting its utility in neuroscience research
Medchemexpress LLC Cathepsin D (CTSD) | 9025-26-7 | 10 U
Cathepsin D (CTSD) is a lysosomal aspartic protease that regulates lysosomal protease activity. Its loss can lead to lysosomal dysfunction and the accumulation of cellular proteins associated with neurodegenerative diseases. This product is also involved in breast cancer metastasis and is used in research on diseases like breast cancer and stroke.
- Lysosomal aspartic protease
- Regulates lysosomal protease activity
- Involved in breast cancer metastasis
- Used in research on neurodegenerative diseases
- Used in research on breast cancer and stroke
Medchemexpress LLC D-Tetrahydropalmatine | 3520-14-7 | MFCD11046348 | 355.43 | 1 ML
D-Tetrahydropalmatine is an isoquinoline alkaloid primarily found in the genus Corydalis. It acts as a dopamine (DA) receptor antagonist, showing preferential affinity for D1 receptors. Additionally, it is identified as a potent inhibitor of organic cation transporter 1 (OCT1).
- Dopamine receptor antagonist
- Preferential affinity toward the D1 receptors
- Potent organic cation transporter 1 (OCT1) inhibitor
- Purity: 99.84%
- Appearance: Solid
- Color: White to light yellow
- Initial source: Plants Papaveraceae Corydalis yanhusuo W. T. Wang
AG Scientific Inc Trehalose Dihydrate 50 G
D-(+)-Trehalose is among the most effective sugars for the stabilization of proteins against damage caused by desiccation or freezing and is noted for its high water-retention capabilities, protecting cells against multiple environmental stressors. It is rarely used as a replacement for conventional sweeteners. It is more commonly used as a cryoprotectant in a variety of cell freezing media. A wide array of implemental enzymes, probes, substrates, antibodies and biology reagents can be kept in trehalose, saving on expensive freezer storage.D-(+)-Trehalose dihydrate is a non-reducing disaccharide, yielding 2 moles of D-glucose upon acid hydrolysis. It is an inducer of autophagy and has properties allowing it to stabilize partially unfolded proteins and inhibit protein aggregation.Trehalose dihydrate has been demonstrated to decrease lysosomal amyloid precursor protein (APP) and inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.
TARGETMOL CHEMICALS INC ISOLIQUIRITIN APIOSIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Isoliquiritin apioside isolated from Glycyrrhizae radix rhizome significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-(kappa)B. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells. Isoliquiritin apioside has marked potential to combat oxidative stress-induced genotoxicity. purity: 99%
![Research Products International Corp Isopropyl-B-D-thio-galactopyranoside [IPTG], 100 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-I56000-100.021.JPG-250.jpg)
Research Products International Corp Isopropyl-B-D-thio-galactopyranoside [IPTG], 100 Grams
IPTG is combined with X-GAL to detect lac+ colonies or cells in a colorimetric assay. Distinguishes recombinants (white) from non- recombinants (blue) in cloning strategies using vectors such as Lambda-11, M13mp 18 and 19, pUC18 and 19, pUR222 containing the lacZ gene.
Dioxane-Free
Water Content: <0.49%